Bring a large pot of salted water to a boil and cook the penne until al dente according to the package directions. Drain and set aside.
Heat olive oil in a large skillet over medium-high heat.
Season the chicken with garlic powder, onion powder, black pepper, and red pepper flakes.
Cook the chicken for 5–7 minutes, stirring occasionally, until browned and fully cooked.
In a small bowl, whisk together the honey, soy sauce, and apple cider vinegar.
Pour the sauce into the skillet with the chicken. Simmer for 2–3 minutes until it thickens into a sticky glaze.
Add the cooked pasta and toss until every piece is coated in the flavorful sauce. This Sticky Honey Pepper Jack Chicken Pasta develops its signature glossy coating during this step.
Sprinkle the shredded pepper jack cheese over the pasta. Cover the skillet for about 2 minutes until the cheese melts.
Garnish with sliced green onions and serve immediately.