Preheat the oven to 375°F (190°C).
Lightly coat a baking dish with nonstick cooking spray.
Rinse the tilapia fillets under cool water and pat them completely dry with paper towels.
Arrange the fillets in a single layer in the prepared baking dish.
Pour the fresh lemon juice evenly over each fillet.
Drizzle the melted butter across the fish.
Sprinkle the minced garlic, dried parsley, and black pepper evenly over the fillets.
Bake the Lemon Garlic Tilapia for about 25–30 minutes, or until the fish turns opaque and flakes easily with a fork.
Remove from the oven and serve immediately with fresh lemon wedges and your favorite side dishes.