Preheat oven to 350°F (175°C) and line a baking sheet with parchment paper.
In a medium bowl, whisk together flour, baking soda, baking powder, and salt. Set aside.
In a large mixing bowl, beat butter, cream cheese, granulated sugar, and brown sugar until light and fluffy, about 3–4 minutes.
Add the egg and vanilla extract and mix until fully combined.
Gradually add the dry ingredients to the wet mixture, mixing until just combined. Avoid overmixing to keep the cookies tender.
Gently fold in blueberries and optional add-ins like white chocolate chips or lemon zest.
Scoop rounded tablespoons of dough onto the prepared baking sheet, spacing them about 2 inches apart.
Bake Irresistible Blueberry Cheesecake Cookies for 12–15 minutes until the edges turn lightly golden and the centers remain soft.
Allow cookies to cool on the baking sheet for 5 minutes before transferring to a wire rack to cool completely.