Preheat your oven to 375°F (190°C).
In a medium bowl, combine the crab meat, chopped shrimp, softened cream cheese, breadcrumbs, lemon juice, parsley, garlic powder, salt, and pepper until evenly mixed.
Carefully cut a pocket into the side of each salmon fillet without slicing all the way through.
Divide the seafood filling evenly and stuff each salmon fillet.
Heat olive oil in a large skillet over medium heat.
Sear each stuffed fillet for 3–4 minutes per side until lightly golden.
Transfer the fillets to a lightly greased baking dish.
Bake the Crab & Shrimp Stuffed Salmon for about 15 minutes, or until the salmon flakes easily with a fork and reaches an internal temperature of 145°F (63°C).
Garnish with fresh parsley and serve immediately with lemon wedges if desired.