Pat the shrimp dry with paper towels. Leave the tails on if preferred.
In a shallow bowl, combine the flour, salt, garlic powder, and onion powder.
Place the panko breadcrumbs in a second shallow bowl.
In a third bowl, whisk together the eggs and milk.
Coat each shrimp in the flour mixture.
Dip the shrimp into the egg mixture, allowing any excess to drip off.
Press each shrimp firmly into the panko breadcrumbs until evenly coated.
Preheat the air fryer to 400°F (200°C) for about 2 minutes.
Spray both sides of the breaded shrimp generously with cooking spray.
Arrange the shrimp in a single layer in the air fryer basket without overcrowding.
Cook for 7 minutes until crispy and golden. No flipping is necessary.
While the shrimp cook, whisk together the buffalo wing sauce, brown sugar, and garlic powder in a large mixing bowl.
Immediately transfer the hot shrimp to the sauce and toss until fully coated.
Garnish with chopped fresh chives and serve your Air Fryer Buffalo Shrimp with Brown Sugar with ranch or blue cheese dressing.